Von Willebrand disease III (Scottish Terrier) in dogs
Heart/BloodRecessive

Von Willebrand disease III (Scottish Terrier) in Dogs

28/08/2025 by Dr Robyn Bird

Category

Heart/Blood

Inheritance

Recessive

Gene

VWF

Breeds at Risk

1+ breeds

Overview

Von Willebrand disease III is a severe inherited blood-clotting disorder caused by mutations in the vWF gene. Different mutations are linked to different breeds, including the Dutch Kooiker, Scottish Terrier, and Shetland Sheepdog. The condition results in a complete or near-complete lack of von Willebrand factor, a protein that plays a critical role in helping blood to clot.

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Symptoms

Symptoms of von Willebrand disease III often become apparent after injury or surgery, when affected dogs experience prolonged and severe bleeding. Excessive bruising may occur even after minor trauma, and in the absence of medical intervention, the bleeding can be life-threatening.

Care and Management

There is no cure for von Willebrand disease III. Management focuses on prevention and preparedness. Pet parents should inform veterinarians of the condition before any surgery or procedure so that blood products are readily available for transfusion if needed. Certain medications, such as NSAIDs and some antibiotics, should be avoided because they increase the risk of bleeding. With careful monitoring and planning, affected dogs can be managed more safely, though the condition remains serious and requires lifelong vigilance.

Breeds Commonly Affected

Scottish terrier

Learn More About Von Willebrand disease III (Scottish Terrier)

What are the signs of von willebrand disease iii in dogs?

Symptoms of von Willebrand disease III often become apparent after injury or surgery, when affected dogs experience prolonged and severe bleeding. Excessive bruising may occur even after minor trauma, and in the absence of medical intervention, the bleeding can be life-threatening. The VWF gene mutation responsible for this condition can be identified with a DNA test. Don't wait on this — book a vet visit for a proper assessment. Our vets can talk you through what you're noticing and help you plan the next steps.

What's the treatment plan for von willebrand disease iii in dogs?

There is no cure for von Willebrand disease III. Management focuses on prevention and preparedness. Pet parents should inform veterinarians of the condition before any surgery or procedure so that blood products are readily available for transfusion if needed. If surgery is recommended, ask your vet about the surgeon's experience with this specific procedure — outcomes can vary significantly with expertise. Our vets can walk you through the management options and help you feel more confident about the path forward.

Can von willebrand disease iii in dogs be cured or treated?

Von Willebrand disease III can't be cured — it's a genetic condition — but with the right management, many affected dogs do well. There is no cure for von Willebrand disease III. Management focuses on prevention and preparedness. Pet parents should inform veterinarians of the condition before any surgery or procedure so that blood products are readily available for transfusion if needed. With the right approach, most affected dogs maintain a good quality of life for years. Regular vet check-ins help keep things on track.

How much does it cost to treat von willebrand disease iii in dogs?

A DNA test for the VWF gene costs $75–$150. Combined with a veterinary exam and any additional workup, initial diagnostics typically run $300–$800 total. Surgery in the US generally runs $2,500–$6,000 depending on complexity, location, and whether a specialist is involved. Regular bloodwork and monitoring typically cost $100–$250 per visit every 3–6 months. Emergency bleeding episodes or cardiac events requiring urgent care can run $1,000–$4,000. Pet insurance taken out before symptoms appear can significantly reduce out-of-pocket costs — check your policy for genetic condition coverage.

Can von willebrand disease iii be prevented through breeding?

Von Willebrand disease III primarily affects Scottish Terriers. The condition is autosomal recessive, caused by a mutation in the VWF gene. DNA testing for the VWF gene is available and gives a definitive answer. Affected dogs need two copies of the mutation. Carriers (one copy) are clinically normal. Never breed two carriers — Carrier × Clear pairings produce no affected puppies. Responsible breeders test both parents before any mating. Our vets can help with breeding guidance or pre-purchase advice for at-risk breeds.

References & Citations

Venta, P.J., Li, J.P., Yuzbasiyan-Gurkan, V., Brewer, G.J., Schall, W.D. : Mutation causing von Willebrand's disease in Scottish terriers Journal of Veterinary Internal Medicine 14:10-19, 2000. Pubmed reference: 10668811.

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