Canine Multifocal Retinopathy 2 in dogs
EyeRecessive

Canine Multifocal Retinopathy 2 in Dogs

02/04/2026 by Dr. Margarette

Category

Eye

Inheritance

Recessive

Gene

BEST1

Breeds at Risk

1+ breeds

Overview

Canine multifocal retinopathy 2 is an eye disease caused by a mutation in the Bestrophin 1 gene. It causes retinal detachment, typically appearing around 3 months of age and progressing slowly until 1 year old. This disease specifically affects Coton de Tulear dogs and is inherited in the autosomal recessive fashion, meaning both parents must be carriers of the mutation for a puppy to be affected.

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Symptoms

Dogs experiencing canine multifocal retinopathy 2 will experience fluid buildup in spots where their retina has detached, leading to gray, tan, orange, or pink “blisters” in the back of the eye. Dogs with this disease may have reduced vision.

Care and Management

There is no known treatment for canine multifocal retinopathy 2. If a dog is experiencing reduced vision due to canine multifocal retinopathy 2, it may be a good idea to add additional lighting, especially at night, and additional supervision.

Breeds Commonly Affected

Coton de tulear

Learn More About Canine Multifocal Retinopathy 2

What does canine multifocal retinopathy 2 look like in dogs?

Dogs experiencing canine multifocal retinopathy 2 will experience fluid buildup in spots where their retina has detached, leading to gray, tan, orange, or pink “blisters” in the back of the eye. Dogs with this disease may have reduced vision. A DNA test for the BEST1 gene can confirm the diagnosis definitively. Schedule a vet visit to get a clear picture. Our vets are also available for a consult if you want guidance before the appointment.

What's the treatment plan for canine multifocal retinopathy 2 in dogs?

There is no known treatment for canine multifocal retinopathy 2. If a dog is experiencing reduced vision due to canine multifocal retinopathy 2, it may be a good idea to add additional lighting, especially at night, and additional supervision. Work closely with your vet to develop a management plan tailored to your dog's specific needs and severity. Reach out to our vets for a consult — we can help you prioritize what matters most and plan for follow-up appointments.

What's the prognosis for a dog with canine multifocal retinopathy 2?

There's no cure for canine multifocal retinopathy 2, but that doesn't mean your dog can't have a good life. This condition is manageable with proper care. There is no known treatment for canine multifocal retinopathy 2. If a dog is experiencing reduced vision due to canine multifocal retinopathy 2, it may be a good idea to add additional lighting, especially at night, and additional supervision. With the right approach, most affected dogs maintain a good quality of life for years. Regular vet check-ins help keep things on track.

How much does it cost to treat canine multifocal retinopathy 2 in dogs?

A DNA test for the BEST1 gene costs $75–$150. Combined with a veterinary exam and any additional workup, initial diagnostics typically run $300–$800 total. Ongoing ophthalmology visits typically cost $100–$250 every 6–12 months. Home adaptations for vision loss (gates, textured mats, nightlights) are modest one-time costs of $50–$200. Pet insurance is worth checking if you had it before any signs appeared — many policies cover treatment of genetic conditions.

Can canine multifocal retinopathy 2 be prevented through breeding?

Canine Multifocal Retinopathy 2 primarily affects Coton De Tulears. The condition is autosomal recessive, caused by a mutation in the BEST1 gene. DNA testing for the BEST1 gene is available and gives a definitive answer. Affected dogs need two copies of the mutation. Carriers (one copy) are clinically normal. Never breed two carriers — Carrier × Clear pairings produce no affected puppies. Responsible breeders test both parents before any mating. Not sure how to interpret your breeder's health testing? Our vets can break it down for you in a quick consult.

References & Citations

Guziewicz, KE., Zangerl, B., Lindauer, SJ., Mullins, RF., Sandmeyer, LS., Grahn, BH., Stone, EM., Acland, GM., Aguirre, GD. : Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease. Invest Ophthalmol Vis Sci 48:1959-67, 2007. Pubmed reference: 17460247. DOI: 10.1167/iovs.06-1374.

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