Early-Onset Progressive Polyneuropathy (Alaskan Malamute)
Muscle/Neurological • NDRG1 • Recessive
Summary
Early-onset progressive polyneuropathy Alaskan Malamute type is a genetic condition affecting Alaskan Malamute dogs that leads to the dysfunction of peripheral nerves. As a result, dogs with the condition are unable to send messages from the brain and spinal cord throughout the rest of the body, causing severe lack of coordination.
Symptoms
Symptoms of the condition typically appear within the first year and a half of life. Dogs experience muscle atrophy and wasting, decreasing ability to control their voice, and even difficulty breathing. They also have a rounded spine and peculiar “bunny-hopping” gait.
Care
There is no cure for early-onset progressive polyneuropathy Alaskan Malamute type. Many find euthanasia to be a compassionate choice for dogs with this condition.
Citations
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkås, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drögemüller, C., Moe, L., Cirera, S., Fredholm, M. : A Gly98Val mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Review
31/03/2026 by Dr.Margarette
Breed
Alaskan malamute