Degenerative Myelopathy (Bernese Mountain Dog)
Muscle/Neurological • SOD1 • Recessive
Summary
Degenerative myelopathy SOD1B is a genetic mutation only found in Bernese Mountain dogs. It is caused by a mutation of the SOD1 gene. It is a disease that affects the spinal cord and leads to loss of hind leg mobility. Degenerative myelopathy SOD1B is a slower form of standard degenerative myelopathy.
Symptoms
Symptoms of degenerative myelopathy SOD1B typically appear around 9 years of age. Dogs with the condition slowly lose both coordination and muscle in their hind legs until they are eventually unable to walk. This process can occur over a 2 year timespan.
Care
There is no known cure for degenerative myelopathy SOD1B. Care for dogs with the condition includes implementing things that make it easier for them to walk, like covering slippery floors with rugs or yoga mats, installing ramps or stairs for tall surfaces, and more. If dogs become fully unable to walk, many turn to euthanasia as a compassionate choice.
Citations
Wininger, F.A., Zeng, R., Johnson, G.S., Katz, M.L., Johnson, G.C., Bush, W.W., Jarboe, J.M., Coates, J.R. : Degenerative myelopathy in a Bernese Mountain Dog with a novel SOD1 missense mutation. J Vet Intern Med 25:1166-70, 2011. Pubmed reference: 21848967. DOI: 10.1111/j.1939-1676.2011.0760.x.
Review
01/04/2026 by Dr.Margarette
Breed
Bernese mountain dog