Cone-Rod Dystrophy 4
Eye • RPGRIP1 • Recessive
Summary
CRD-NPHP4 and cord1-PRA (also known as CRD4 or CRD SWD) are the two known types of Cone-Rod Dystrophy in dachshunds. Genetic mutations in the RPGRIP1 gene contribute to progressive retinal atrophy (PRA). These mutations are autosomal recessive, meaning both parents must carry the mutation for the offspring to have symptoms.
Symptoms
Symptoms of CRD in dachshunds include the loss of color vision, reduced visual acuity, day blindness, aversion to bright light, loss of peripheral vision, and eventual total blindness.
Care
There is no cure for PRA or CRD. Instead, care focuses on maintaining a consistent and safe environment to help dogs adapt to their vision loss. Regular eye exams can also be helpful, and genetic testing can inform breeding decisions.
Citations
Mellersh, CS., Boursnell, ME., Pettitt, L., Ryder, EJ., Holmes, NG., Grafham, D., Forman, OP., Sampson, J., Barnett, KC., Blanton, S., Binns, MM., Vaudin, M. : Canine RPGRIP1 mutation establishes cone-rod dystrophy in miniature longhaired dachshunds as a homologue of human Leber congenital amaurosis. Genomics 88:293-301, 2006. Pubmed reference: 16806805. DOI: 10.1016/j.ygeno.2006.05.004.
Review
04/04/2026 by Dr. Margarette
Breed
Miniature dachshund