How do I tell if my Australian Shepherd has NCL6?
Reviewed by Dial A Vet Team
Category
Muscle/Neurological
Traits
Neuronal Ceroid Lipofuscinosis 6
Question Number
Q1
Pet Owner Description
Our Aussie is about 18 months old and his vision seems to be getting worse. He's also acting strangely — more anxious and confused. Could this be NCL6?
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Answer
Those signs at that age in an Australian Shepherd are concerning for NCL6, a rare lysosomal storage disorder caused by a CLN6 gene mutation. Signs typically appear around 18 months and include vision loss, behavioral changes, difficulty with coordination, and seizures. The progressive nature is the key indicator — symptoms that steadily worsen over weeks to months. DNA testing for the CLN6 mutation is definitive. Please book a neurological exam soon. Our vets can help guide the diagnostic process.
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