How do I tell if my Border Collie has NCL5?

Those signs in a Border Collie at that age are concerning for NCL5. It typically appears between 15 and 20 months and progresses with behavioral changes (losing interest, confusion), loss of coordination, vision problems, and eventually seizures. The progressive nature is key — signs that keep getting worse over weeks to months in a young dog of an affected breed should raise alarm. NCL5 is caused by a mutation in the CLN5 gene. DNA testing is definitive. Please book a neurological exam soon. Our vets can help you understand the diagnostic pathway and what results would mean.