Can intestinal cobalamin malabsorption be prevented through breeding (Beagle)?

Intestinal Cobalamin Malabsorption primarily affects Beagles. The condition is autosomal recessive, caused by a mutation in the CUBN gene. DNA testing for the CUBN gene is available and gives a definitive answer. Affected dogs need two copies of the mutation. Carriers (one copy) are clinically normal. Never breed two carriers — Carrier × Clear pairings produce no affected puppies. Ask your breeder for DNA test results on both parents before committing to a puppy. Our vets can discuss breed-specific screening and help you understand what test results mean.