How do I tell if my Alaskan Malamute puppy has polyneuropathy?
Reviewed by Dial A Vet Team
Category
Muscle/Neurological
Traits
Early-Onset Progressive Polyneuropathy (Alaskan Malamute)
Question Number
Q1
Pet Owner Description
Our Malamute puppy is 10 months old and his back legs are getting weak and wobbly. He used to be full of energy. Could this be the polyneuropathy condition?
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Answer
The pattern you're describing — progressive weakness, especially in the back legs, in a young Malamute — is consistent with Alaskan Malamute Polyneuropathy (AMPN). It's caused by a mutation in the NDRG1 gene and typically shows up within the first 18 months. Signs start as exercise intolerance and hind-limb weakness, progress to bunny-hopping, muscle wasting, and sometimes a voice change from laryngeal nerve involvement. A DNA test for the NDRG1 mutation gives a definitive answer. Our vets can help you plan the right diagnostic pathway.
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