Pet Health

EPI (Exocrine Pancreatic Insufficiency) in dogs and cats

Learn about Exocrine Pancreatic Insufficiency (EPI) in dogs and cats, its symptoms, causes, and effective treatment options to ensure your pet’s health.
Author: Veterinary Team
Dial A Vet
Updated
June 6, 2025
|
Published
June 6, 2025
A healthy dog and cat sitting together, symbolizing the importance of dietary management for EPI in pets.

Video Call an Aussie Vet now for just $49 AUD

Dial A Vet is available in Australia, NZ, Canada, United States & Canada!
Speak to A Vet Now

Is your dog or cat suddenly losing weight, experiencing chronic diarrhea, or acting lethargic? These troubling signs can leave any pet parent feeling helpless. One potential underlying cause is Exocrine Pancreatic Insufficiency (EPI), a condition that affects your pet's ability to digest food properly. Understanding EPI and knowing how to support your furry friend can make a world of difference in their health and quality of life.

⚠️ What to Watch For

EPI in dogs and cats often goes unnoticed in the early stages. However, as the condition progresses, certain symptoms become more apparent. Here’s what to look out for:

  • Chronic diarrhea or loose stools
  • Weight loss despite a good appetite
  • Greasy or foul-smelling stools
  • Excessive gas or bloating
  • Lethargy or decreased energy
  • Dry, dull coat or hair loss
  • Increased appetite (sometimes even eating non-food items)

If your pet is showing one or more of these signs, it’s essential to seek veterinary advice promptly. These symptoms can also overlap with other conditions, so proper diagnosis is key.

🔍 Possible Causes

EPI occurs when the pancreas doesn’t produce enough digestive enzymes to break down food. Without these enzymes, your pet can't absorb essential nutrients, leading to malnutrition. But what causes this issue in the first place?

  • Genetics: Certain dog breeds, like German Shepherds and Rough Collies, are genetically predisposed to EPI. In cats, the condition is less common but can occur.
  • Chronic Pancreatitis: Inflammation of the pancreas can damage its ability to produce enzymes over time.
  • Autoimmune Disorders: In some cases, the immune system mistakenly attacks the pancreas.
  • Pancreatic Atrophy: This refers to the shrinking of pancreatic tissue, often seen in younger dogs with hereditary EPI.

Regardless of the cause, the result is the same: your pet struggles to digest and absorb the nutrients they need to thrive.

✅ What You Can Do at Home

Managing EPI requires a combination of medical treatment and lifestyle adjustments. Here’s how you can support your pet at home:

  • Enzyme Supplements: Pets with EPI need pancreatic enzyme replacements mixed into their food. These supplements help break down proteins, fats, and carbohydrates, making them digestible.
  • Special Diet: Work with your vet to find a highly digestible diet that’s low in fiber and moderate in fat. Avoid foods with fillers or low-quality ingredients.
  • Frequent, Small Meals: Feeding smaller meals throughout the day can improve digestion and nutrient absorption.
  • Monitor Weight and Stool Quality: Regularly check your pet's weight and watch for changes in stool consistency. This helps gauge how well the treatment is working.
  • Probiotics: Adding probiotics can support gut health and reduce diarrhea.

Consistency is key when managing EPI. Stick to your pet’s treatment plan and dietary routine to avoid setbacks.

💡 When to Call a Vet

While at-home management plays a vital role, veterinary oversight is essential for pets with EPI. Contact your vet if you notice any of the following:

  • Symptoms not improving despite enzyme supplementation
  • Sudden weight loss or worsening diarrhea
  • Signs of malnutrition, such as a brittle coat or muscle loss
  • Changes in behavior, such as lethargy or decreased appetite

Your vet may adjust your pet’s enzyme dosage, recommend additional tests, or explore other treatment options. Early intervention can prevent complications and improve your pet’s quality of life.

FAQs

Q: Can EPI be cured?
A: EPI is a lifelong condition, but with proper management, most pets can live healthy, happy lives. Enzyme supplements and a tailored diet are crucial.

Q: Is EPI common in cats?
A: EPI is relatively rare in cats compared to dogs. However, it can occur, particularly in cats with chronic pancreatitis.

Q: How long does it take for enzyme supplements to work?
A: Many pets show improvement within a few weeks of starting enzyme supplements. However, it may take longer to see full results, especially in severe cases.

Book a $49 online vet consultation at https://www.dialavet.com for fast, expert advice.

References

While every effort is made to ensure the accuracy of this content - including vet review where applicable - this article is for informational purposes only and is not a substitute for professional veterinary advice, diagnosis, or treatment. If your pet is unwell or you are concerned, please speak with a licensed veterinarian. You can book a $49 online consultation with our veterinary team  😄
Speak to A Vet Now

🐾 You Might Also Like