What's the difference genetically between D M and early onset D M genetically/ how do they interact?

Hi there! Let's unpack DM, or Degenerative Myelopathy, in a way that’s easy to understand. This is a condition that affects the spinal cord in dogs and can lead to mobility issues, particularly in older dogs. The key player in this is a mutation in the SOD1 gene, which is involved in the body's defense against oxidative stress.



In most cases, DM becomes apparent in dogs around 8 years old. However, in some rare instances, especially in certain breeds, symptoms can show up earlier, and we refer to this as early-onset DM. The genetic difference isn’t so much a different mutation, but rather it’s about how other genetic factors in a dog might influence when the condition starts to appear. More research is ongoing to understand these complex interactions.



While DM itself is progressive, there are several things you can do at home to help your pup. Keeping them active with low-impact exercise like swimming can be beneficial. However, watch for signs such as wobbling, weakness in the hind limbs, or dragging paws. If you notice these, it’s a good idea to consult with a vet as soon as possible.



If you’re concerned about your dog's risk or symptoms, a video consult with one of our veterinarians at Dial A Vet could provide you with more tailored advice. They're here to help!