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Question:

Proheart 12 reaction? side effects

I'm feeling pretty anxious right now and could really use some advice. I took my dog, Max, to the vet a couple of days ago for his routine check-up, and he ended up getting the ProHeart 12 injection for heartworm prevention. The vet assured me it was safe, but ever since, Max just isn't himself. He’s been really lethargic and not interested in his food, which is so unlike him. I even noticed he’s been panting a bit more than usual, and his energy is just nonexistent. Has anyone else experienced similar side effects in their dogs after this injection? I’m just at a loss and worried sick. Any insights or similar stories would really help put my mind at ease. Thanks so much in advance.

Answer:

Hello there! I'm glad you're reaching out about your concerns regarding ProHeart 12. It’s completely natural to be attentive to your pet’s well-being, especially after they receive a treatment.



ProHeart 12 is a long-acting injectable heartworm prevention for dogs. While it's generally safe and quite effective, some dogs might experience mild side effects. These can include vomiting, diarrhea, decreased appetite, or lethargy shortly following the injection. Typically, these symptoms are mild and resolve on their own.



To help your pet feel more comfortable at home, make sure they have access to plenty of water and a quiet, cozy place to rest. Light meals may be easier on their stomach if they’re experiencing tummy troubles.



However, be on the lookout for more serious reactions. If you notice your dog has difficulty breathing, facial swelling, severe vomiting or diarrhea, or seems unusually weak or disoriented, these could be signs of an allergic reaction, and you should seek veterinary attention promptly.



If your pet's symptoms persist or if you notice anything unusual that worries you, I recommend booking a video consult with one of our vets at Dial A Vet. We’re here to help and provide guidance specific to your dog’s needs. Stay calm and give your furry friend some extra love and cuddles today!

Answered by

Louise - Senior Veterinary Nurse, Dial A Vet

June 23, 2025

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The "Ask a Vet" forum on Dial A Vet offers general information and helpful tips on pet health, but it's not a substitute for professional veterinary care. The advice here doesn't create a veterinarian-client-patient relationship, and our vets can't diagnose or treat your pet remotely. For emergencies or specific medical concerns, always contact your local veterinarian immediately. Your pet's health is unique, and decisions should only be made after consulting with a qualified professional. By using this forum, you acknowledge these limitations and agree to seek in-person veterinary advice for all your pet's health needs. View our content guidelines.
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