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Question:

Interaction b/w Doxycycline & L-Lysine Powder Supplement in CATS

folks, I'm really desperate for some guidance here. My sweet girl, Luna, who’s been my companion for the past six years, recently got prescribed Doxycycline for some respiratory issues she's been having. She’s always been on L-Lysine powder to help with her feline herpes, and I'm suddenly second-guessing if that's still okay with the new meds. I've been feeling really anxious about giving her both, worried about any possible interaction. Has anyone else dealt with this before? Is it safe to continue with the L-Lysine while she’s on the antibiotic? My vet is wonderful but I couldn’t reach them today, and I could really use some advice from anyone who has been in a similar situation. Luna means the world to me, and I just want to make sure I'm doing right by her. Thanks in advance for any help you can offer!

Answer:

Hello there!



Thanks for reaching out with your question about your cat. It's great that you're being proactive about your pet's health. Doxycycline is an antibiotic often used to treat bacterial infections, and L-Lysine is a supplement commonly used to support immune health, especially for cats prone to upper respiratory infections.



Generally, there are no known harmful interactions between doxycycline and L-Lysine when given together to cats. They can work side by side quite nicely. However, it's important to give doxycycline with food to minimize the risk of stomach upset. L-Lysine can be mixed into your cat's food or given separately as instructed on the packaging.



Keep an eye out for any signs of gastrointestinal distress, such as vomiting, diarrhea, or a decrease in appetite, which could necessitate a vet visit. Also, watch for signs like lethargy, or any difficulty breathing, which could indicate a more serious issue.



You're doing a wonderful job caring for your cat, but sometimes a little guidance is needed. If you have lingering concerns, consider booking a video consult with one of us at Dial A Vet. We're here to help you and your feline friend every step of the way!

Answered by

Louise - Senior Veterinary Nurse, Dial A Vet

June 19, 2025

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The "Ask a Vet" forum on Dial A Vet offers general information and helpful tips on pet health, but it's not a substitute for professional veterinary care. The advice here doesn't create a veterinarian-client-patient relationship, and our vets can't diagnose or treat your pet remotely. For emergencies or specific medical concerns, always contact your local veterinarian immediately. Your pet's health is unique, and decisions should only be made after consulting with a qualified professional. By using this forum, you acknowledge these limitations and agree to seek in-person veterinary advice for all your pet's health needs. View our content guidelines.
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